Darwin Nunez scored as Uruguay kicked off their Copa America campaign with a 3-1 victory over Panama in Miami, Florida.
The 25-year-old Liverpool striker volleyed home at the near post with five minutes of regular time remaining, doubling Uruguay's lead after defender Ronald Araujo opened the scoring at 16 minutes.
Left-back Matias Vina added a third in stoppage time for the 15-time champions before defender Michael Amir Murillo netted a consolation goal for Panama.
"When it comes to Uruguay's aspirations, we will see that and build it match by match," said Uruguay manager Marcelo Bielsa.
"My expectation is that each match will increasingly help us to improve our level. Uruguay has players of a very good level, and we need to see if I can build with those players."
Uruguay has been in fine form and is tipped to impress at the Copa America after defeating Argentina and Brazil in World Cup qualifiers over the past year.
In Group C's other match, Christian Pulisic scored one goal and set up another as the United States beat Bolivia 2-0 in their tournament opener in Arlington, Texas.
The AC Milan forward curled in a fine opener after three minutes before setting up Monaco striker Folarin Balogun, who added a second just before halftime with a low left-footed finish.